Fig. 2.

Context-dependent DAF spectrum of synonymous mutations. a Definition of isoaccepting, non-isoaccepting and nonsynonymous mutations. b Illustration of isoaccepting and non-isoaccepting codon context. c Rapid recharging of tRNAs in the isoaccepting codon context. d Box-and-whisker plots displaying the DAF spectrum of different categories of synonymous mutations. Wilcoxon rank sum test was used to calculate p-value. ***Represents p-value < 0.001; n.s., not significant. Multiple testing correction was performed to adjust the p-value. Length of multiple testing correction was set to the number of tests performed