Table 2.

Details of Organ Involvement in NAXOS-Carvajal Syndrome Associated with Blisters and Nail Anomalies.

Reference	Organ involvement
	Heart	Blisters	PPK	Hair	Nails	Teeth
27	mild RV dilatation VT of RV origin	pemphigus foliaceous-like vesicles on the extremities	none	woolly	not reported	not reported
18	BiV dilatation and systolic dysfunction	blisters and erosions, especially at sites of mechanical trauma	focal and striate with fissuring	near-total alopecia	thick and dystrophic	not reported
19	BiV dilatation	superficial, mucocutaneous, scalp and face blisters blistering only develops after severe mechanical stress since 6 years of age	localized minimal palmar involvement	woolly and sparse	thick, detached and dystrophic	enamel dysplasia
12	severe RV or BiV dysfunction SCD in BiV involvement	epidermolytic plantar blisters and erythema, followed by keratoderma	mild palmar keratosis plantar keratosis in pressure areas	woolly, rough, light-colored	onychogryphosis	not reported
present case	BiV dilatation and systolic dysfunction	epidermolytic bulla, erosions and pigmentations throughout the body, not on the palms and soles	mild and focal	curly, fine brown change	thick, detached and dystrophic	normal

BiV: biventricular, LV: left ventricle, PPK: palmoplantar keratosis, RV: right ventricle, SCD: sudden cardiac death, VT: ventricular tachycardia