Table 2.
Significant associations of test scores with common PD-risk SNPs*.
| Clinical feature | SNP | Nearest gene | Distance to nearest gene (kb) | MAF this study | Sex | Model | Unadjusted p-value | Bonferroni corrected p-value | β | 95% CI |
|---|---|---|---|---|---|---|---|---|---|---|
| GDS score | rs11343 rs6497339 |
SYT17
SYT17 |
0 0 |
43.1 43.8 |
Males Both Both |
GENO-2DF GENO-2DF GENO-2DF |
1.35 × 10−4
7.17 × 10−5 2.22 × 10−4 |
0.0166 0.00910 0.0281 |
NA NA NA |
|
| UPDRS IV- dyskinesia subscore | rs12528068 | RIMS1 | 108.6 | 28.6 | Females | Additive GENO-2DF |
5.25 × 10−5
1.33 × 10−4 |
0.00635 0.0161 |
0.254 NA |
0.132–0.375 |
| UPDRS VI-Schwab and England | rs12283611 | DLG2 | 0 | 44.0 | Males | GENO-2DF | 1.98 × 10−4 | 0.0243 | NA |
*
Covariates: sex, age-at-encounter, years-since-diagnosis, and for MMSE, years of education.