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. 2021 Apr 14;9:666122. doi: 10.3389/fchem.2021.666122

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Copyright © 2021 Weiss, Loi, Sterle, Balsollier, Tomašič, Pieters, Gobec and Anderluh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic depiction of fragment screening and workflow of the fragment-based design approach; synthesis and evaluation of 1^st set of 22 compounds (evaluation at 1 mM by UDP-Glo™ assay) and 2^nd set of 15 compounds (evaluation at 100 μM by fluorescence activity assay). 2^nd set includes compounds based on F20 elongated with various amines.