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. 2021 Apr 14;9:666122. doi: 10.3389/fchem.2021.666122

Table 1.

Fragments and compounds inhibition potency against OGT.

Frag. Inline graphic OGT residual activity [%]
Fluorescence activity assay UDP-Glo™ assay
F20 graphic file with name fchem-09-666122-i0002.jpg 41 ± 5 60 ± 1
3b graphic file with name fchem-09-666122-i0003.jpg 44 ± 5 48 ± 2
4b graphic file with name fchem-09-666122-i0004.jpg 82 ± 7 94 ± 2
4c graphic file with name fchem-09-666122-i0005.jpg 65 ± 9 9 ± 0
Comp. graphic file with name fchem-09-666122-i0006.jpg OGT residual activity [%]
Fluorescence activity assay UDP-Glo™ assay
6a graphic file with name fchem-09-666122-i0007.jpg 77 ± 5 29 ± 1
6b graphic file with name fchem-09-666122-i0008.jpg 21 ± 1 68 ± 0
6c graphic file with name fchem-09-666122-i0009.jpg 88 ± 4 83 ± 1
6d graphic file with name fchem-09-666122-i0010.jpg 65 ± 1 75 ± 0
6e graphic file with name fchem-09-666122-i0011.jpg 72 ± 0 95 ± 2
6f graphic file with name fchem-09-666122-i0012.jpg 77 ± 8 40 ± 0
7a graphic file with name fchem-09-666122-i0013.jpg 63 ± 3 64 ± 1
8a graphic file with name fchem-09-666122-i0014.jpg 64 ± 0 85 ± 0
8b graphic file with name fchem-09-666122-i0015.jpg 64 ± 4 69 ± 1
8c graphic file with name fchem-09-666122-i0016.jpg 79 ± 0 77 ± 1
8d graphic file with name fchem-09-666122-i0017.jpg 71 ± 4 100 ± 0
OSMI-4* 0 ± 0 0 ± 0

Results are presented as mean ± SD from two independent experiments, each performed in triplicate. Compounds were tested at 240 μM;

*

OSMI-4 was tested at 50 μM.