Table 1.
Characteristics of included case series.
| Study | Keast and Fraser, 2004 [26] | Ferri et al., 2007 [27] | Gunter et al., 2015 [30] |
|---|---|---|---|
| Country | Canada | England | Germany |
| Study design | Case series | Case series | Case series |
| Total number of patients (%) | 4 (100%) | 14 (100%) | 3 (100%) |
| Males | 4 (100%) | 3 (21.4%) | 1 (33.3%) |
| Females | 0 | 11 (78.6%) | 2 (66.7%) |
| Mean age (years) | 59 ± 19 | 52.7 ± 12.1 | 65 ± 4 |
| Wound aetiology | Pressure ulcers in refractory anaemia | Skin ulcers in systematic sclerosis | Diabetic ulcers |
| Type of treatment | subcutaneously | subcutaneously | topical |
| Treatment period | 6 weeks | 8 weeks | 3 weeks (patient 1) 25 weeks (patient 2) 9 weeks (patient 3) |
| Total number of wounds | 12 (100%) | 14 (100%) | 3 (100%) |
| Average wound size (cm2) | Not reported | 27.6 ± 28 | 6 (patient 1) 40 (patient 2) Not reported (patient 3) |
| Number of wounds with complete healing (%) | Not reported (ulcer status was improved for all patients) | 6 (42.85%) | 3 (100%) |
| Mean duration for complete healing (days) | Not reported (data was reported after 6 weeks of treatment) | 135 ± 33.6 (3–6 months) | 17.3 ± 10.1 |
| Follow-up period (months) | Not reported | 6–12 | 9 |