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The mechanism of activation of NLRP3 inflammasome by endoplasmic reticulum stress. ER, endoplasmic reticulum; NLRP3, NLRP3 inflammasome; ASC, apoptosis-related spot-like protein containing caspase recruitment domain; ERK1, extracellular signal regulated kinase 1; NF-κB, nuclear factor kappa B; ROS, reactive oxygen species; TXNIP, thioredoxin interacting protein; IL, interleukin.
