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. 2021 Apr 14;12:666162. doi: 10.3389/fphar.2021.666162

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Copyright © 2021 Wang, Jing, Bi, Li, Ma, Yang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neutrophil elastase induces chondrocytes apoptosis through cleaved caspase-3. (A) Representative histograms of cleaved caspase-3 levels of chondrocytes were shown. (B) Cell associated mean relative fluorescence intensities. Data are mean ± SEM; n = 3. ***p < 0.001. (C) The fluorescence pattern of annexin V-FITC/PI staining chondrocytes. (D) Percentages of annexin V positive cells for chondrocytes treated with NE and Z-VAD-FMK. Data are mean ± SEM; n = 3. ***p < 0.001. (E) Western blot of ERK1/2 phosphorylation, total ERK1/2, caspase-3 and cleaved caspase-3 levels of chondrocytes treated with NE.