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. 2021 Apr 14;12:666162. doi: 10.3389/fphar.2021.666162

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Copyright © 2021 Wang, Jing, Bi, Li, Ma, Yang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sivelestat decreased apoptosis of articular chondrocytes and impeded the loss of cartilage in the knee joint from neutrophil elastase induced rat osteoarthritic model. (A) Macroscopic view, micro-CT image and 3D image of the specimens from sham group, OA model group and treatment groups. (B) Representative safranin O-fast green staining of the knee joint in sham group, OA model group and treatment groups. (C) OARSI scores based on staining results. Data are mean ± SEM; n = 3. **p < 0.01. (D) Western blot of ERK1/2 phosphorylation, total ERK1/2, caspase-3 and cleaved caspase-3 levels of articular cartilage from rat model. (E) Western blot of ERK1/2 phosphorylation, total ERK1/2, caspase-3 and cleaved caspase-3 levels of articular cartilage from healthy donors and OA patients.