Table 1.
Demographic and clinical characteristics of four different datasets used for the various analyses.
| Demographic and clinical characteristics | Training/validation/testing MS datasets (n = 1,672) | Scan rescan dataset MS HC (n = 3) (n = 2) | Inter-scanner dataset MS HC (n = 125) (n = 52) | Clinical MS dataset (n = 49) | ||
|---|---|---|---|---|---|---|
| Number of females, n (%) | 1174 (71) | 2 (66.7) | 2 (1 0 0) | 90 (72) | 36 (69.2) | 37 (77.8) |
| Age in years, mean (SD) | 41.2 (13.8) | 32 (9.2) | 30 (1.8) | 42.9 (11.5) | 39.5 (9.4) | 30.7 (7.9) |
| Disease duration in years, mean (SD) | 12.3 (13.2) | 6.8 (9.3) | NA | 11.4 (9.8) | NA | 4.9 (5.2) |
| EDSS, median (IQR) | 2.5 (1.0–6.0) | 1.5 (0) | NA | 2.5 (2.0–4.5) | NA | 2.0 (1.5–5.0) |
| Disease subtype, mean (SD) RR SP PP |
923 (55.2) 507 (30.3) 242 (14.5) |
3 (1 0 0) |
NA |
77 (61.6) 35 (28) 13 (10.4) |
NA |
36 (73.4) 13 (26.6) 0 (0) |
| T2 lesion volume, mean (SD) | 14.1 (17.5) | 7.2 (2.1) | 0 (0) | 12.3 (12.5) | 0.2 (0) | 14.4 (17.2) |
| DeepGRAI volume, mean (SD) | 14.0 (1.6) | 15.6 (1.5) | 16.9 (1.2) | 13.2 (2.1) | 15.9 (1.5) | 14.1 (2) |
| FIRST volume, mean (SD) | 14.4 (1.8) | 15.7 (1.4) | 17.1 (1) | 13.0 (2) | 16.0 (1.4) | 14 (2.1) |
Legend: MS – multiple sclerosis; HC – healthy controls; SD – standard deviation; NA – not available; EDSS – Expanded Disability Status Scale; IQR-interquartile range; RR – relapsing-remitting; SP – secondary progressive; PP – primary progressive.
The volumes are expressed in milliliters.