1 Epworth sleepiness scale ‐ first arm data/parallel studies |
3 |
268 |
Mean Difference (IV, Random, 95% CI) |
0.64 [‐0.57, 1.86] |
2 Epworth sleepiness score ‐ crossover studies |
4 |
336 |
Epworth score (Fixed, 95% CI) |
0.54 [‐0.29, 1.38] |
3 Apnoea Hypopnea Index ‐ first arm data/parallel studies |
4 |
283 |
Mean Difference (IV, Random, 95% CI) |
9.08 [4.78, 13.38] |
4 Apnoea Hypopnea Index ‐ crossover studies |
7 |
464 |
AHI/hr (Fixed, 95% CI) |
7.97 [6.38, 9.56] |
5 Quality of life score (SAQLI) ‐ first arm data/parallel studies |
3 |
192 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.03 [‐0.35, 0.28] |
6 Quality of life ‐ crossover studies |
1 |
|
General Health score (Fixed, 95% CI) |
Totals not selected |
7 Functional outcomes of sleep questionnaire ‐ crossover studies |
2 |
256 |
FOSQ Units (Fixed, 95% CI) |
‐0.18 [‐0.42, 0.07] |
7.1 Total Score |
2 |
256 |
FOSQ Units (Fixed, 95% CI) |
‐0.18 [‐0.42, 0.07] |
8 Short‐form 36 (quality of life) ‐ crossover studies |
2 |
|
SF36 units (Fixed, 95% CI) |
Totals not selected |
8.1 Physical component score |
1 |
|
SF36 units (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
8.2 Mental component score |
1 |
|
SF36 units (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
8.3 Total score |
1 |
|
SF36 units (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
9 Hospital Anxiety Depression Scale ‐ parallel group trials |
0 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
9.1 Anxiety |
0 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
9.2 Depression |
0 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
10 Hospital Anxiety Depression Scale ‐ crossover studies |
1 |
|
HADS Units (Fixed, 95% CI) |
Totals not selected |
10.1 Anxiety |
1 |
|
HADS Units (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
10.2 Depression |
1 |
|
HADS Units (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
11 Cognitive performance ‐ SteerClear |
1 |
|
Cows hit (Fixed, 95% CI) |
Totals not selected |
12 Maintenance of Wakefulness test (MWT) ‐ crossover studies |
2 |
256 |
Mins (Fixed, 95% CI) |
0.69 [‐1.56, 2.94] |
13 Minimum saturation (%) ‐ first arm data/parallel studies |
3 |
189 |
Mean Difference (IV, Fixed, 95% CI) |
4.59 [2.55, 6.64] |
14 Minimum saturation ‐ crossover studies |
4 |
279 |
% (Fixed, 95% CI) |
5.16 [3.25, 7.06] |
15 Arousals ‐ first arm data/parallel studies |
3 |
189 |
Mean Difference (IV, Fixed, 95% CI) |
5.21 [2.48, 7.94] |
16 Arousals ‐ crossover studies |
6 |
367 |
Arousals/hr (Fixed, 95% CI) |
2.24 [0.43, 4.05] |
17 Blood pressure outcomes ‐ crossover studies |
1 |
|
mmHg (Fixed, 95% CI) |
Totals not selected |
17.1 Mean 24hr arterial pressure |
0 |
|
mmHg (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
17.2 Mean 24hr systolic BP |
1 |
|
mmHg (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
17.3 Mean 24hr diastolic BP |
1 |
|
mmHg (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
17.4 Mean diurnal arterial pressure |
0 |
|
mmHg (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
17.5 Mean nocturnal arterial pressure |
0 |
|
mmHg (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
17.6 Mean nocturnal diastolic |
1 |
|
mmHg (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
18 Blood pressure outcomes (parallel studies) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
18.1 Mean 24hr arterial pressure |
0 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
18.2 Mean 24hr systolic BP |
0 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
18.3 Mean 24hr diastolic BP |
0 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
18.4 Mean morning systolic BP |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
18.5 Mean evening systolic BP |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
18.6 Mean morning diastolic BP |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
18.7 Mean evening diastolic BP |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
19 Patient Preference |
4 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
20 Patient preference ‐ treatment success in both arms |
2 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
21 Withdrawals ‐ first arm data/parallel studies |
6 |
411 |
Odds Ratio (M‐H, Fixed, 95% CI) |
2.05 [1.15, 3.67] |
22 Side‐effects by type ‐ crossover studies |
2 |
|
Peto Odds Ratio (Peto, Fixed, 95% CI) |
Subtotals only |
22.1 Pressure on face |
1 |
38 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.20 [0.05, 0.85] |
22.2 Pressure in mouth |
1 |
38 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
7.81 [0.47, 129.75] |
22.3 TMJ pain |
2 |
134 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
18.00 [8.62, 37.57] |
22.4 Removal during sleep |
1 |
96 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
3.50 [1.43, 8.57] |
22.5 Sleep disruption |
1 |
96 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.67 [0.28, 1.61] |
22.6 Excessive salivation |
1 |
96 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
8.88 [2.27, 34.79] |
22.7 Tooth damage |
1 |
96 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
7.71 [0.78, 75.97] |
22.8 Leak |
1 |
96 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.11 [0.03, 0.37] |
22.9 Dry upper airway |
1 |
96 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.12 [0.02, 0.74] |
22.10 Stuffy nose |
1 |
96 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.12 [0.03, 0.49] |
22.11 Inconvenience |
1 |
96 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.12 [0.02, 0.63] |
23 Side‐effects by severity ‐ crossover studies |
2 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
23.1 None |
2 |
86 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.57 [0.24, 1.36] |
23.2 Mild |
2 |
86 |
Odds Ratio (M‐H, Fixed, 95% CI) |
5.19 [1.65, 16.30] |
23.3 Moderate |
2 |
86 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.02 [0.35, 2.95] |
23.4 Severe |
2 |
86 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.23 [0.04, 1.16] |
24 Preference ‐ treatment success in either treatment arm |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |