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. 2006 Jan 25;2006(1):CD004435. doi: 10.1002/14651858.CD004435.pub3

Comparison 2. Oral appliance versus continuous positive airways pressure.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Epworth sleepiness scale ‐ first arm data/parallel studies 3 268 Mean Difference (IV, Random, 95% CI) 0.64 [‐0.57, 1.86]
2 Epworth sleepiness score ‐ crossover studies 4 336 Epworth score (Fixed, 95% CI) 0.54 [‐0.29, 1.38]
3 Apnoea Hypopnea Index ‐ first arm data/parallel studies 4 283 Mean Difference (IV, Random, 95% CI) 9.08 [4.78, 13.38]
4 Apnoea Hypopnea Index ‐ crossover studies 7 464 AHI/hr (Fixed, 95% CI) 7.97 [6.38, 9.56]
5 Quality of life score (SAQLI) ‐ first arm data/parallel studies 3 192 Mean Difference (IV, Fixed, 95% CI) ‐0.03 [‐0.35, 0.28]
6 Quality of life ‐ crossover studies 1   General Health score (Fixed, 95% CI) Totals not selected
7 Functional outcomes of sleep questionnaire ‐ crossover studies 2 256 FOSQ Units (Fixed, 95% CI) ‐0.18 [‐0.42, 0.07]
7.1 Total Score 2 256 FOSQ Units (Fixed, 95% CI) ‐0.18 [‐0.42, 0.07]
8 Short‐form 36 (quality of life) ‐ crossover studies 2   SF36 units (Fixed, 95% CI) Totals not selected
8.1 Physical component score 1   SF36 units (Fixed, 95% CI) 0.0 [0.0, 0.0]
8.2 Mental component score 1   SF36 units (Fixed, 95% CI) 0.0 [0.0, 0.0]
8.3 Total score 1   SF36 units (Fixed, 95% CI) 0.0 [0.0, 0.0]
9 Hospital Anxiety Depression Scale ‐ parallel group trials 0   Mean Difference (IV, Fixed, 95% CI) Totals not selected
9.1 Anxiety 0   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
9.2 Depression 0   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
10 Hospital Anxiety Depression Scale ‐ crossover studies 1   HADS Units (Fixed, 95% CI) Totals not selected
10.1 Anxiety 1   HADS Units (Fixed, 95% CI) 0.0 [0.0, 0.0]
10.2 Depression 1   HADS Units (Fixed, 95% CI) 0.0 [0.0, 0.0]
11 Cognitive performance ‐ SteerClear 1   Cows hit (Fixed, 95% CI) Totals not selected
12 Maintenance of Wakefulness test (MWT) ‐ crossover studies 2 256 Mins (Fixed, 95% CI) 0.69 [‐1.56, 2.94]
13 Minimum saturation (%) ‐ first arm data/parallel studies 3 189 Mean Difference (IV, Fixed, 95% CI) 4.59 [2.55, 6.64]
14 Minimum saturation ‐ crossover studies 4 279 % (Fixed, 95% CI) 5.16 [3.25, 7.06]
15 Arousals ‐ first arm data/parallel studies 3 189 Mean Difference (IV, Fixed, 95% CI) 5.21 [2.48, 7.94]
16 Arousals ‐ crossover studies 6 367 Arousals/hr (Fixed, 95% CI) 2.24 [0.43, 4.05]
17 Blood pressure outcomes ‐ crossover studies 1   mmHg (Fixed, 95% CI) Totals not selected
17.1 Mean 24hr arterial pressure 0   mmHg (Fixed, 95% CI) 0.0 [0.0, 0.0]
17.2 Mean 24hr systolic BP 1   mmHg (Fixed, 95% CI) 0.0 [0.0, 0.0]
17.3 Mean 24hr diastolic BP 1   mmHg (Fixed, 95% CI) 0.0 [0.0, 0.0]
17.4 Mean diurnal arterial pressure 0   mmHg (Fixed, 95% CI) 0.0 [0.0, 0.0]
17.5 Mean nocturnal arterial pressure 0   mmHg (Fixed, 95% CI) 0.0 [0.0, 0.0]
17.6 Mean nocturnal diastolic 1   mmHg (Fixed, 95% CI) 0.0 [0.0, 0.0]
18 Blood pressure outcomes (parallel studies) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
18.1 Mean 24hr arterial pressure 0   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
18.2 Mean 24hr systolic BP 0   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
18.3 Mean 24hr diastolic BP 0   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
18.4 Mean morning systolic BP 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
18.5 Mean evening systolic BP 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
18.6 Mean morning diastolic BP 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
18.7 Mean evening diastolic BP 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
19 Patient Preference 4   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
20 Patient preference ‐ treatment success in both arms 2   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
21 Withdrawals ‐ first arm data/parallel studies 6 411 Odds Ratio (M‐H, Fixed, 95% CI) 2.05 [1.15, 3.67]
22 Side‐effects by type ‐ crossover studies 2   Peto Odds Ratio (Peto, Fixed, 95% CI) Subtotals only
22.1 Pressure on face 1 38 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.20 [0.05, 0.85]
22.2 Pressure in mouth 1 38 Peto Odds Ratio (Peto, Fixed, 95% CI) 7.81 [0.47, 129.75]
22.3 TMJ pain 2 134 Peto Odds Ratio (Peto, Fixed, 95% CI) 18.00 [8.62, 37.57]
22.4 Removal during sleep 1 96 Peto Odds Ratio (Peto, Fixed, 95% CI) 3.50 [1.43, 8.57]
22.5 Sleep disruption 1 96 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.67 [0.28, 1.61]
22.6 Excessive salivation 1 96 Peto Odds Ratio (Peto, Fixed, 95% CI) 8.88 [2.27, 34.79]
22.7 Tooth damage 1 96 Peto Odds Ratio (Peto, Fixed, 95% CI) 7.71 [0.78, 75.97]
22.8 Leak 1 96 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.11 [0.03, 0.37]
22.9 Dry upper airway 1 96 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.12 [0.02, 0.74]
22.10 Stuffy nose 1 96 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.12 [0.03, 0.49]
22.11 Inconvenience 1 96 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.12 [0.02, 0.63]
23 Side‐effects by severity ‐ crossover studies 2   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
23.1 None 2 86 Odds Ratio (M‐H, Fixed, 95% CI) 0.57 [0.24, 1.36]
23.2 Mild 2 86 Odds Ratio (M‐H, Fixed, 95% CI) 5.19 [1.65, 16.30]
23.3 Moderate 2 86 Odds Ratio (M‐H, Fixed, 95% CI) 1.02 [0.35, 2.95]
23.4 Severe 2 86 Odds Ratio (M‐H, Fixed, 95% CI) 0.23 [0.04, 1.16]
24 Preference ‐ treatment success in either treatment arm 1   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected