Engleman 2002.

Methods	Randomised crossover study comparing oral appliance and CPAP. Randomisation was stratified by severity of OSA defined by AHI of less than or equal to 15. Randomisation was conducted by blocks of 4.
Participants	12 women and 36 men completed the trial (51 were recruited). Baseline age 46 +/‐9, baseline AHI 31+/‐26, baseline Epworth 14 +/‐4. Inclusion criteria: Age 18‐70, AHI 5 or more, 2 or more symptoms of OSA including sleepiness (Epworth score of 8 or more) and driving impairment. Exclusion criteria: Patients with fewer than 4 teeth remaining in either arch, coexisting narcolepsy, periodic limb movement (more than 10 per hour), major medical illness, shift work, or residency more than 50 miles from Edinburgh.
Interventions	Participants randomised to either CPAP or one of two OA devices (occlusal and non‐occlusal coverage). Duration: 4 months (2 months on each treatment).
Outcomes	AHI, subjective efficacy, symptom score, Epworth score, FOSQ, SF‐36 health transition, physical and mental component scores.
Notes	Jadad score 3
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Described as randomised, other information not available
Allocation concealment?	Unclear risk	Information not available
Blinding? All outcomes	High risk	OA and CPAP compared