Fleetham 1998.

Methods	Randomised, prospective, unblinded parallel group study comparing oral appliance with nasal CPAP. Study duration 3 months
Participants	101 patients were recruited. Inclusion criteria AHI>10. 51 participants were randomised to receive CPAP and 50 were randomised to receive OA therapy. 96 men were recruited. Baseline demographics: AHI: CPAP: 37.6 +/‐22.8; OA: 38.7 +/‐22.2. Min SaO2: CPAP: 75.8 +/‐12.7; OA: 73.6 +/‐11.8. Age: CPAP: 49.0 +/‐9.4; OA: 46.2 +/‐11.3. ESS: CPAP: 12.8+/‐4.1; OA: 11.1 +/‐4.9. BMI: CPAP: 32.0 +/‐5.5; OA: 31.4 +/‐5.7. SAQLI: CPAP: 4.2 +/‐1.1; OA: 4.2 +/‐1.0.
Interventions	Participants were randomised to either oral appliance or nCPAP for a period of three months.
Outcomes	AHI, Epworth sleepiness score, minimum SaO2, Quality of life index.
Notes	Jadad score 1
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Described as randomised, other information not available
Allocation concealment?	Unclear risk	Information not available
Blinding? All outcomes	High risk	OA and CPAP compared