Table 1.
Summary of T1D and T2D patient iPSC cell line studies for diabetes-in-a-dish
| Study reference | Diabetic state | Cell type generated | In vivo transplantation | Additional notes |
|---|---|---|---|---|
| Leite et al. (2020)32 | T1D | SC-β and SC-α cells | no | isogenic co-culture with immune cells |
| Wang et al. (2019)33 | T2D | β-like cells | no | microarray, RNA-seq, and ChIP-seq data from PPs |
| Dwivedi et al. (2019)34 | T2D | β-like cells | – | RNA-seq |
| Sui et al. (2018)24 | T1D | NT-iPSC-β cells | yes, prevent diabetes onset | NT patient SCs |
| Cosentino et al. (2018)27 | T2D | β-like cells | no | – |
| Amin et al. (2018)35 | T1D, T2D | SC-β cells | yes, study in vivo cells | chemical screen, RNA-seq of sorted β sorted cells |
| Millman et al. (2016)36 | T1D | SC-β cells | yes, prevent diabetes onset | microarray data |
| Thatava et al. (2013)37 | T1D | Pancreatic islet-like cells | – | microarray data of iPSCs |