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. 2021 Apr 12;2(4):100243. doi: 10.1016/j.xcrm.2021.100243

Figure 6.

Figure 6

Paired testing of mucosal and blood specimens from 8 PLH

(A) Percent T cells of total cells in rectal and ectocervical biopsies; n = 6 per tissue type. Boxes and whiskers: median; interquartile range, <1.5 × IQR and >1.5 × IQR.

(B) DSI-corrected intact proviral copies per 1 million T cells in PBMCs and rectal biopsies.

(C) DSI-corrected intact proviral copies per 1 million T cells in PBMCs and cervical biopsies.

(D) Correlation between viral loads measured from cervicovaginal lavage versus intact proviral copies in cervical T cells by ddPCR. Axes in (D) are pseudo-log10 scaled, transitioning to a linear scale approaching zero. Samples from the Discordant Shedding Cohort were run with 6 replicate wells for assay2 (assay1 was not performed on these samples) and two replicate wells for the reference assay. For the ACTU-2100 Cohort, we ran 3–11 replicate wells for assay2 and 2–6 wells for the reference assay, depending on how much gDNA was available.