Table 4.
Laboratory parameters and lung function tests in the two groups of patients (normal or altered DLCO/VA % of predicted)
| Normal Lung function tests (n = 71) | Abnormal Lung function tests (n = 23) | All patients (n = 94) | |
|---|---|---|---|
| Humoral parameters: White blood cells (#/mm3) | 6200 ± 2600 | 6000 ± 3100 | 6170 ± 2730 |
| Granulocytes (#/mm3) | 4700 ± 2500 | 4400 ± 2900 | 4590 ± 2590 |
| Monocytes (#/mm3) | 410 ± 220 | 430 ± 210 | 410 ± 210 |
| Lymphocytes (#/mm3) | 2010 (980) | 2320 (1140) | 2014 (980) |
| Hemoglobin (g/dl) | 13.0 ± 1.5 | 12.7 ± 2.1 | 12.9 ± 1.64 |
| Platelets (# × 103/mm3) | 216 ± 87 | 211 ± 78 | 215 ± 84 |
| CRP (mg/L) | 93.8 ± 74.2 | 85.5 ± 91.7 | 91.8 ± 78.4 |
| Ferritin (µg/L) | 147 (140) | 119 (125) | 141 (142) |
| D-dimer (ng/ml) | 270 ± 325 | 384 ± 350* | 297 ± 332 |
| Creatinine (mg/dl) | 0.96 ± 0.27 | 0.97 ± 0.53 | 0.96 ± 0.35 |
| AST | 53 ± 44 | 36 ± 20* | 49 ± 40 |
| ALT | 42 ± 43 | 29 ± 22 | 39 ± 39 |
| INR | 1.26 ± 0.26 | 1.32 ± 0.40 | 1.3 ± 0.3 |
| aPTT (s) | 32.5 ± 3.5 | 35.0 ± 5.8 | 33.1 ± 4.3 |
| Lung function test | |||
| FVC (L) | 3.88 ± 1.04 | 3.48 ± 081 | 3.8 ± 1.0 |
| FEV1 (L) | 3.04 ± 0.76 | 2.71 ± 0.72 | 3.0 ± 0.8 |
| DLCO (mL/min/mmHg) | 21.3 ± 6.4 | 17.8 ± 4.3** | 20.4 ± 6.2 |
| VA (ml/min) | 5.1 ± 1.2 | 5.1 ± 0.9 | 5.1 ± 1.1 |
| VA % predicted | 83.9% ± 14.0% | 93.7% ± 14.8% | 84.8% ± 14.2% |
| DLCO % predicted | 87.2 ± 18.2 | 74.7 ± 13.6** | 84.2 ± 18.4 |
| DLCO/VA% predicted (= KCO) | 98.8 ± 17.9 | 66.8 ± 6.5*** | 91.2 ± 21.0 |
| FEV1/FVC | 79.1% ± 9.1% | 77.0% ± 7.94% | 78.6% ± 8.8% |
| DLCO/VA | 4.2 ± 0.7 | 3.5 ± 0.6*** | 4.03 ± 0.8 |
CRP C-reactive protein, AST aspartate transaminase, ALT alanine aminotransferase, INR international normalized ratio, aPTT activated partial thromboplastin time, FVC forced vital capacity, FEV1 forced expiratory volume in one second, DLCO diffusing capacity of lung for carbon monoxide, VA alveolar volume, pred predicted
One-way ANOVA: *p < 0.05, **0 < 0.01, ***p < 0.001 vs. normal