Table 2.

Tissue tropism of porcine bocavirus.

Tissue	Key findings	References
Lymph nodes	The infection rates of PBoV in the PMWS-affected pigs were twice higher than in the non-PMWS affected pigs. The co-infection of PBoV along with the TTSV and PCV-2 might have facilitate the development of PMWS	Blomström et al. (2009)
	The co-existence of two bocavirus strain within the same fecal sample revealing inter and intra host genetic diversity	Lau et al. (2011)
	The genetic diversity of the circulating bocavirus strains in Xinjiang belong to three subgroups of three different genetic groups	Meng et al. (2018)
Gastrointestinal tract	The prevalence rate of PBoV was higher in stool samples and these viruses multiply in the intestinal tract of piglets	Cheng et al. (2010)
Respiratory tract	The first evidence of infection of weaning piglets with respiratory tract symptoms representing an emerging virus for swine respiratory tract diseases	Zhai et al. (2010)
Nasopharyngeal sample	PBoV were higher in nasopharyngeal samples in deceased pigs than in healthy pigs	Lau et al. (2011)
Mesenteric lymph nodes	The mesenteric lymph node had the highest detection rate suggesting the pathogenesis of PBoV infection involves the lymphoid tissues	Jacob et al. (2018)
Inguinal lymph nodes	25% of the organ tested were positive for PBoV	Jacob et al. (2018)
Spleen	23.5% of the spleen tested were positive for PBoV	Jacob et al. (2018)
Tonsil	Out of 80 tonsil samples, 23 samples were positive for the PBoV	Saekhow and Ikeda (2014)
	The tonsil had the second highest detection rate suggesting the pathogenesis of PBoV infection involves the lymphoid tissues	Jacob et al. (2018)
Lung	Porcine parvovirus 4 was similar to PBoV. After inoculation of tissue homogenate in the colostrum deprived piglets, clinical symptoms were observed. But due to coinfection with PCV-2. It was not clear whether PPV4 can cause disease on its own or contributed to the disease phenomenon	Cheung et al. (2010)
	One lungs tissue sample was positive for the PBoV without coinfection of the PCV-2, suggesting PBoV as not the risk factor the Hungarian pigs	Csagola et al. (2012)
	The first description of the prevalence of PBoV in Korean swine herds with the mean positive rate of 34.9%	Choi et al. (2014)
	33.3% of lungs tissues were positive for PBoV	Jacob et al. (2018)
Kidney	PBoV was detected from kidney tissues of two pigs suggesting the ability of virus to replicate within kidney cells causing renal pathology	Jacob et al. (2018)
Cerebral tissue	By using fluorescent in situ hybridization for histologic detection of encephalomyelitis assigns a potential role of PBoV in provoking CNS lesions	Pfankuche et al. (2016)
Liver	25% of liver tissue were positive for PBoV	Jacob et al. (2018)