Table 2.

Results of the models adjusted for PRS-SCZ from the imputed datasets.

	GAF symptoms			GAF disabilities
	Coefficient	95% CI	p-value	Coefficient	95% CI	p-value
EUGEI
Patients	−1.60	−2.51 to −0.69	0.001	−1.58	−2.48 to −0.68	0.001
Siblings	−3.08	−3.81 to −2.35	<0.001	−2.52	−3.21 to −1.83	<0.001
Controls	−1.58	−2.19 to −0.97	<0.001	−1.26	−1.76 to −0.76	<0.001
GROUP (replication)a
Patients	−1.57	−2.58 to −0.55	0.003	−1.45	−2.51 to −0.39	0.007

Notes: All analyses were adjusted for age, sex, and education (1 = “No qualification,” 2 = “With qualification (secondary),” 3 = “Tertiary,” 4 = “Vocational,” and 5 = “University”), PRS-SCZ, and 10 principal components. Analyses in the EUGEI were additionally adjusted for country (Turkey, Spain, and Serbia).

Abbreviations: CI, confidence interval; EUGEI, the European Network of National Networks Studying Gene–Environment Interactions in Schizophrenia; GAF, Global Assessment of Functioning; GROUP, the Genetic Risk and Outcome of Psychosis; PRS-SCZ, polygenic risk score for schizophrenia.

^aThe patient population of the GROUP served as the replication dataset.