Measuring the size of the HIV-1 latent reservoir and the dynamics of HIV-1 proviral landscape
(A) Comparison of inducible RNA-based, proviral sequencing-based, and DNA ddPCR-based methods that measure the size of HIV-1 latent reservoir.
(B) Caveats of using HIV-1 near full-length proviral sequencing and multiplex ddPCR to profile the dynamics of intact versus defective HIV-1 proviral landscape. Ψ, packaging signal. RRE, Rev-response element.