. Author manuscript; available in PMC: 2022 Mar 1.

Published in final edited form as: J Periodontol. 2021 Feb 13;92(3):348–358. doi: 10.1002/JPER.19-0441

TABLE 2.

Uni- and multivariable analysis of periodontal activity versus MACE

Model Predictor	Model Covariables^a	Model outcome
		MACE
		Standardized HR (95% CI)	P
Inflammation of the periodontium (PD_inflammation) ^a	None	2.25 (1.47 to 3.44)	<0.001
	Age and sex	1.94 (1.31 to 2.87)	0.001
	Framingham Risk Score^b	1.79 (1.16 to 2.75)	0.008
	Age, sex, smoking, HTN, and DM	1.93 (1.31 to 2.84)	0.001
	Statin use	2.09 (1.36 to 3.23)	0.001
	CAC	2.19 (1.41 to 3.39)	<0.001
	Periodontal bone loss^c	3.16 (1.60 to 6.22)	0.001
	Arterial inflammation^d	1.80 (1.12 to 2.89)	0.016

Continuous variables were standardized; a backward (conditional) model was used when more than one covariable was entered into the model.

The predictor, Inflammation of the periodontium, was entered as a continuous variable.

Framingham Risk Score data for these sub-analyses are available in 106 individuals.

Periodontal bone loss was evaluated on a five-point scale; the analysis excluded individuals who were edentulous.

Arterial Inflammation is measured as target-to-background on positron emission tomography.

DM, diabetes mellitus; HTN, arterial hypertension; CAC, coronary artery calcium; HR, hazard ratio, CI, confidence interval.