. Author manuscript; available in PMC: 2021 Apr 28.

Published in final edited form as: J Thorac Oncol. 2019 Jun 27;14(11):1982–1988. doi: 10.1016/j.jtho.2019.06.015

Table 1.

IC50 values of Ba/F3 cells expressing mutant EGFR constructs for various generations of EGFR-TKIs.

	Osimertinib	Erlotinib	Afatinib	Neratinib	Poziotinib
EGFR L858R	4.20 nM	16.50 nM	0.16 nM	3.42 nM	0.15 nM
EGFR L858R/M766Q	50.62 nM	4,450 nM	46.40 nM	4.32 nM	1.33 nM
EGFR L858R/T790M/C797S	1,630 nM	7,400 nM	1,500 nM	1,830 nM	5,300 nM