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. 2021 Apr 13;9:606527. doi: 10.3389/fcell.2021.606527

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Copyright © 2021 Cai, Lu, Wang, Shi, Yuan and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing of SH2B3 augments TMZ-induced suppression of mouse xenograft tumors growth. (A) Representative images of tumors derived from U87 control or shRNA cells. Scale bar = 1 cm. (B) Weight of indicated tumors. (C) The volume of indicated tumors. (D) Immunohistochemistry staining with tumors derived from U87 control or SH2B3 shRNA cells using Ki67 antibody and representative images were shown. Scale bar = 100 μm. (E) Quantification data for panel (D). Control or shRNA means indicated tumors derived from cells expressing control shRNA or SH2B3 shRNA, respectively. *, **, and *** indicate p < 0.05, p < 0.01, and p < 0.0001, respectively.