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. 2021 Apr 13;9:606527. doi: 10.3389/fcell.2021.606527

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Copyright © 2021 Cai, Lu, Wang, Shi, Yuan and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing of SH2B3 inhibits STAT3 activation. (A) Target genes of STAT3 were dramatically decreased after silencing of SH2B3 in U87 (left panel) and U251 (right panel) cells. (B) Western blot of phosphorylation form of STAT3 (Y705). (C) SH2B3 mRNA expression was positively correlated with STAT3 target gene in indicated data sets. (D) SH2B3 physically binds to gp130. (E) Gp130 physically binds to SH2B3. (F) Representative images of co-immunofluorescence staining between SH2B3 and gp130 in patient-derived clinical specimens. Scale bar = 50 μm. (G) Quantification data for panel (F). (H) Silencing of gp130 significantly attenuates p-STAT3 (Y705) expression. *, **, and *** indicate p < 0.05, p < 0.01, and p < 0.0001, respectively.