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. 2021 Apr 28;14:116. doi: 10.1186/s12920-021-00966-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Construction of a Risk Assessment Model based on CCRL2, HSPA1A and SCG2. Univariate Cox (a) and multivariate Cox (b) regression analyses for CCRL2, HSPA1A and SCG2. c–e Overall survival analysis for CCRL2, HSPA1A and SCG2 by univariate Cox regression analysis. f The normalized expression of CCRL2, HSPA1A and SCG2 in CRC. Risk scores (g) and survival outcomes (h) of each case of CRC based on CCRL2 and HSPA1A. Risk scores (i) and survival outcomes (j) of each case of CRC based on CCRL2 and HSPA1A. Overall survival analysis of the risk model constructed based on 2 IR-DEGs (CCRL2 and HSPA1A) (k) and 1 DEG (SCG2) (l). m The expression of CCRL2, HSPA1A and SCG2 in different groups of CRC. The ROC curve of the risk model based on 2 IR-DEGs (CCRL2 and HSPA1A) (n) and 1 DEG (SCG2) (o). The AUC values of the 3-year, 5-year and 10-year survival based on 2 IR-DEGs (CCRL2 and HSP1A1) (p) and 1 DEG (SCG2) (q)