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Time-to-first on-treatment exacerbation by quartile. a Moderate; b moderate/severe; c severe. Time-to-first on-treatment exacerbation from Week 16 by Week 16 fibrinogen quartile. Interaction of treatment with fibrinogen quartile p-values for a–c are 0.695, 0.599 and 0.783 respectively: Quartile 1: < 2.780 g/L; Quartile 2: ≥ 2.780 g/L; Quartile 3: < 3.830 g/L; Quartile 4: ≥ 3.830 g/L
