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. 2021 Apr 26;13:69. doi: 10.1186/s13073-021-00884-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Increased seizure susceptibility and abnormal EEG in heterozygous 1b deletion mice. a–d Latency measures were observed after an i.p. injection of 80 mg/kg PTZ over the course of a 30-min trial. Reduced latencies to first jerk, loss of righting, generalized clonic seizure, and full tonic extension were observed in 1b^+/− mice when compared to WT littermate controls. EEG was collected using a wireless telemetry system before and after an i.p. injection of 80 mg/kg PTZ. e, f Representative EEG traces of WT and 1b^+/− mice during baseline EEG recording and subsequent PTZ response. Powerband calculations and spiking events were automatically scored. g 1b^+/− mice had significantly more spiking events and spike trains during baseline EEG acquisition when compared to WT. Scored spiking events are shown on a 1b^+/− representative trace and indicated by red lines. h 1b^+/− mice also had significantly higher power across all frequency bins, Delta (0–4 Hz), Theta (4–8 Hz), Alpha (8–12 Hz), Sigma (12–16 Hz), and Beta (16–30) during baseline when compared to controls. Finally, seizure susceptibility was confirmed with EEG after PTZ administration. i, j Reduced latencies to seizure onset and death were observed in 1b^+/−mice. *, p < 0.05, t test