Fig. 5.

Scn1a 1b homozygous deletion mice exhibit learning and memory impairments without confounds in gross motor abilities. Recognition memory was assessed using a novel object recognition assay. a 1b^−/− mice did not spend more time sniffing the novel object over the familiar object. 1b^+/− and WT performed with typical preference. b All genotypes showed no preference for either the left or right object during the familiarization phase indicating no innate side bias confounds of lack of object exploration, in the novel object recognition trials. *, p < 0.05, paired-test within genotype using the familiar versus novel object for comparison. c Working memory impairments were observed by lower percentages of spontaneous alternation in the Y-Maze. *, p < 0.05, one-way ANOVA. d No genotype differences in horizontal (d) or vertical (e) activity counts in the 1b^+/− and 1b^−/− mice compared to their wildtype littermate controls. f 1b^−/− deletion mice were hyperactive in total activity during two different 5-min bins of the 30-min assay. Moreover, when total activity is summed and re-graphed as a bar graph, comparisons between 1b^−/− versus WT and 1b^+/− in total movement were observed. Analyses include both males and females. *p < 0.05, repeated measures ANOVA, main effect of genotype