Figure 1.

Overview of the differentially expressed ferroptosis signatures in ESCC

(A) Expression profiles of ferroptosis-related genes in normal and tumor samples in GEO: GSE20347, GSE23400, and GSE75241 datasets. Genes were clustered according to their expression. Red color represents high expression, and blue color represents low expression. (B) Venn diagram showing the dysregulated ferroptosis genes common to the four datasets. (C and D) Graph showing the GO and KEGG analysis based on the Metascape Online, bar plot, and network showing the distribution and relationship of the different functions. (E) PPI network and MCODE showing the hub genes in the ferroptosis gene set.