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. 2021 Apr 27;22:394. doi: 10.1186/s12891-021-04272-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Age-related decline in Gal-1 levels in peripheral blood serum and bone marrow microenvironment in 18-month-old mice and the correlation of trabecular bone volume fraction with Gal-1 levels. Serum was prepared from peripheral blood of 6- and 18-month-old mice. ELISA was employed to quantify the levels of Gal-1 (a). The correlation of serum Gal-1 levels with BV/TV of femur (b), tibia (c), and L1 vertebrae (d) was analyzed. Femur bone marrow aspirates were prepared from 6- and 18-month-old mice. Gal-1 was quantified by ELISA (e). Immunohistochemistry assay was employed to investigate Gal-1 expression in femur bone marrow of 6- and 18-month-old mice (f). The correlation of bone marrow Gal-1 levels with BV/TV of femur (g) was analyzed. Data were shown as the means ± SD. *: p < 0.05, ***: p < 0.001, 18 mo vs. 6 mo