Table 3.
Absolute concentrations of major bile acids in controls and patients
|
BA
|
Unamidated
|
G-BA
|
T-BA
|
Total
|
|
mean ± SE, µmol/L
| ||||
| Controls | ||||
| Unsulfated BA | ||||
| LCA | 0.000 ± 0.00 | 0.000 ± 0.00 | 0.000 ± 0.00 | 0.001 ± 0.00 |
| UDCA | 0.004 ± 0.00 | 0.033 ± 0.00 | 0.002 ± 0.00 | 0.038 ± 0.00 |
| CDCA | 0.003 ± 0.00 | 0.008 ± 0.00 | 0.002 ± 0.00 | 0.013 ± 0.00 |
| DCA | 0.022 ± 0.00 | 0.011 ± 0.00 | 0.002 ± 0.00 | 0.035 ± 0.00 |
| HDCA | 0.01 ± 0.00 | 0.00 ± 0.00 | ND | 0.007 ± 0.00 |
| MDCA | 0.060 ± 0.01 | ND | ND | 0.058 ± 0.01 |
| CA | 0.179 ± 0.03 | 0.067 ± 0.00 | 0.009 ± 0.00 | 0.255 ± 0.03 |
| MCA | 0.028 ± 0.00 | 0.287 ± 0.02 | 0.041 ± 0.00 | 0.356 ± 0.02 |
| HCA | 0.008 ± 0.00 | 0.016 ± 0.00 | 0.001 ± 0.00 | 0.026 ± 0.00 |
| Other BA1 | 0.160 ± 0.01 | - | - | 0.160 ± 0.01 |
| Total unsulfated | 0.464 ± 0.04 | 0.422 ± 0.02 | 0.057 ± 0.00 | 0.943 ± 0.05 |
| Sulfated BA | ||||
| LCA | 0.010 ± 0.00 | 0.780 ± 0.04 | 0.220 ± 0.01 | 1.010 ± 0.05 |
| UDCA | 0.450 ± 0.02 | 1.040 ± 0.05 | 0.030 ± 0.00 | 1.520 ± 0.07 |
| CDCA | 0.070 ± 0.01 | 2.380 ± 0.13 | 0.060 ± 0.00 | 2.510 ± 0.13 |
| DCA | 0.010 ± 0.00 | 2.900 ± 0.14 | 0.220 ± 0.02 | 3.130 ± 0.16 |
| CA | 0.004 ± 0.00 | 0.056 ± 0.01 | 0.126 ± 0.01 | 0.190 ± 0.01 |
| Total sulfated | 0.535 ± 0.03 | 7.170 ± 0.28 | 0.650 ± 0.03 | 8.350 ± 0.31 |
| Overall total | 1.000 ± 0.05 | 7.590 ± 0.29 | 0.710 ± 0.03 | 9.300 ± 0.33 |
| Patients | ||||
| Unsulfated BA | ||||
| LCA | 0.004 ± 0.00 | 0.001 ± 0.00 | 0.0001 ± 0.00 | 0.005 ± 0.00 |
| UDCA | 0.079 ± 0.03 | 0.410 ± 0.17 | 0.012 ± 0.00 | 0.500 ± 0.21 |
| CDCA | 0.020 ± 0.00 | 0.090 ± 0.01 | 0.100 ± 0.02 | 0.210 ± 0.03 |
| DCA | 0.040 ± 0.00 | 0.040 ± 0.00 | 0.010 ± 0.00 | 0.090 ± 0.01 |
| HDCA | 0.010 ± 0.00 | 0.00 ± 0.00 | ND | 0.010 ± 0.00 |
| MDCA | 0.050 ± 0.01 | ND | ND | 0.050 ± 0.01 |
| CA | 0.240 ± 0.03 | 0.550 ± 0.07 | 0.320 ± 0.08 | 1.120 ± 0.14 |
| MCA | 0.120 ± 0.02 | 1.940 ± 0.29 | 0.730 ± 0.09 | 2.790 ± 0.34 |
| HCA | 0.010 ± 0.00 | 0.170 ± 0.02 | 0.090 ± 0.02 | 0.270 ± 0.04 |
| Other BA1 | 0.860 ± 0.13 | - | - | 0.860 ± 0.13 |
| Total | 0.460 ± 0.04 | 0.42 ± 0.02 | 0.06 ± 0.00 | 5.910 ± 0.57 |
| Sulfated BA | ||||
| LCA | 0.030 ± 0.01 | 2.230 ± 0.20 | 0.650 ± 0.06 | 2.910 ± 0.24 |
| UDCA | 1.560 ± 0.23 | 15.30 ± 2.68 | 1.230 ± 0.27 | 18.10 ± 3.08 |
| CDCA | 0.190 ± 0.03 | 18.70 ± 1.79 | 1.910 ± 0.38 | 20.80 ± 2.07 |
| DCA | 0.040 ± 0.01 | 4.280 ± 0.54 | 0.520 ± 0.07 | 4.840 ± 0.58 |
| CA | 0.080 ± 0.01 | 0.910 ± 0.13 | 1.030 ± 0.21 | 2.010 ± 0.31 |
| Total | 1.900 ± 0.24 | 41.40 ± 4.12 | 5.340 ± 0.74 | 48.70 ± 4.77 |
| Overall total | 3.330 ± 0.33 | 44.60 ± 4.46 | 6.610 ± 0.85 | 54.60 ± 5.20 |
1
Other bile acids: Nor-deoxycholic acid, 12-oxo-chenodeoxycholic acid, 3-dehydrocholic acid, 6-oxo-lithocholic acid, 7-oxo-lithocholic acid, 12-oxo-lithocholic acid, isolithocholic acid, and isodeoxycholic acid.
ND: Not detected; -: Not quantified; BA: Bile acids; G: Glycine; T: Taurine; CDCA: Chenodeoxycholic acid; CA: Cholic acid; LCA: Lithocholic acid; UDCA: Ursodeoxycholic acid; DCA: Deoxycholic acid; HDCA: Hyodeoxycholic acid; MDCA: Murideoxycholic acid; MCA: Muricholic acid; HCA: Hyocholic acid.