Table 5.
Representative bile acids concentrations and indices in medium- vs low- model for end-stage liver disease patients
|
BA (µmol/L) or BA indices
|
Low-MELD
|
Medium-MELD
|
Medium- vs low-MELD
|
|||
|
mean
|
SE
|
mean
|
SE
|
Ratio
|
P
value
|
|
| Total BA | 59.2 | 7.94 | 116 | 24.8 | 1.96 | 1.000 |
| Total LCA | 3.40 | 0.35 | 6.01 | 1.72 | 1.77 | 0.175 |
| Total UDCA | 24.4 | 5.34 | 18.6 | 6.30 | 0.76 | 0.172 |
| Total CDCA | 18.3 | 2.31 | 71.4 | 16.3 | 3.90 | 0.000 |
| Total DCA | 5.30 | 0.96 | 6.08 | 1.47 | 1.15 | 1.000 |
| Total HDCA | 0.01 | 0.00 | 0.01 | 0.00 | 0.61 | 1.000 |
| Total MDCA | 0.05 | 0.01 | 0.06 | 0.01 | 1.28 | 1.000 |
| Total CA | 2.80 | 0.48 | 10.6 | 4.45 | 3.79 | 0.000 |
| Total MCA | 3.58 | 0.57 | 2.15 | 0.46 | 0.60 | 0.210 |
| Total HCA | 0.25 | 0.04 | 0.86 | 0.36 | 3.48 | 0.002 |
| % LCA | 9.31 | 0.53 | 7.97 | 1.47 | 0.86 | 1.000 |
| % UDCA | 23.1 | 1.29 | 14.3 | 2.52 | 0.62 | 1.000 |
| % CDCA | 34.7 | 1.21 | 55.6 | 3.17 | 1.60 | 0.000 |
| % DCA | 13.8 | 0.65 | 7.18 | 1.33 | 0.52 | 0.005 |
| % HDCA | 0.04 | 0.01 | 0.01 | 0.00 | 0.32 | 0.661 |
| % MDCA | 0.29 | 0.04 | 0.13 | 0.03 | 0.43 | 1.000 |
| % CA | 5.75 | 0.30 | 8.70 | 1.25 | 1.51 | 0.145 |
| % MCA | 7.15 | 0.48 | 3.70 | 0.91 | 0.52 | 0.000 |
| % HCA | 0.46 | 0.07 | 0.75 | 0.15 | 1.61 | 0.148 |
| Total Unamidated | 4.24 | 0.55 | 2.87 | 0.72 | 0.68 | 0.062 |
| Total G-amidated | 48.4 | 6.89 | 92.8 | 19.7 | 1.92 | 1.000 |
| Total T-amidated | 6.58 | 1.04 | 20.7 | 7.30 | 3.15 | 0.040 |
| % Amidation | 86.7 | 0.87 | 94.4 | 1.28 | 1.09 | 0.005 |
| % G-amidation | 75.5 | 0.96 | 77.2 | 2.73 | 1.02 | 1.000 |
| % T-amidation | 11.2 | 0.64 | 17.1 | 2.15 | 1.53 | 0.002 |
| Total unsulfated | 6.99 | 0.93 | 9.04 | 2.42 | 1.29 | 1.000 |
| Total sulfated | 52.3 | 7.21 | 107 | 23.2 | 2.05 | 1.000 |
| % Sulfation | 82.4 | 0.81 | 88.3 | 1.34 | 1.07 | 0.009 |
| Total mono-OH | 3.40 | 0.35 | 6.01 | 1.72 | 1.77 | 0.175 |
| Total di-OH | 48.1 | 7.01 | 96.2 | 20.9 | 2.00 | 1.000 |
| Total tri-OH | 6.63 | 0.90 | 13.6 | 4.90 | 2.06 | 0.301 |
| % Mono-OH | 9.31 | 0.53 | 7.97 | 1.47 | 0.86 | 1.000 |
| % Di-OH | 72.0 | 0.90 | 77.2 | 2.14 | 1.07 | 0.058 |
| % Tri-OH | 13.4 | 0.59 | 13.1 | 1.40 | 0.98 | 0.274 |
| Total 12α-OH | 8.55 | 1.23 | 16.8 | 4.86 | 1.96 | 0.053 |
| Total non-12α-OH | 50.7 | 7.21 | 99.6 | 21.5 | 1.96 | 1.000 |
| 12α-OH/non12α-OH | 0.30 | 0.01 | 0.20 | 0.02 | 0.68 | 0.135 |
| CA/CDCA | 0.21 | 0.01 | 0.17 | 0.03 | 0.81 | 1.000 |
| % 12α-OH | 21.0 | 0.69 | 16.1 | 1.44 | 0.77 | 0.008 |
| % non-12α-OH | 79.0 | 0.69 | 83.9 | 1.44 | 1.06 | 0.008 |
| Total primary | 25.0 | 3.08 | 85.1 | 19.5 | 3.41 | 0.000 |
| Total secondary | 34.3 | 5.78 | 31.3 | 8.05 | 0.91 | 0.316 |
| Primary/secondary | 2.19 | 0.24 | 5.02 | 1.16 | 2.29 | 1.000 |
| % Primary | 48.1 | 1.40 | 68.7 | 3.10 | 1.43 | 0.014 |
| % Secondary | 51.9 | 1.40 | 31.3 | 3.10 | 0.60 | 0.014 |
BA: Bile acids; MELD: Model for end-stage liver disease; G: Glycine; T: Taurine; CDCA: Chenodeoxycholic acid; CA: Cholic acid; LCA: Lithocholic acid; UDCA: Ursodeoxycholic acid; DCA: Deoxycholic acid; HDCA: Hyodeoxycholic acid; MDCA: Murideoxycholic acid; MCA: Muricholic acid; HCA: Hyocholic acid.