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. 2021 Apr 28;12:2460. doi: 10.1038/s41467-021-22814-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Changes in the genetic composition of the lung population over time. Plotted points show the portion of isolates of the ancestral strain and mutants that evolved in situ (n = 11 or 12 isolates per time point). Data points were offset for visual clarity and error bars show 90% confidence intervals in proportions calculated by the normal approximation to the binomial distribution. B Meropenem resistance and fitness of respiratory isolates (mean + /− s.e.m; n > 5 isolates per group). Fitness was measured as log-phase growth rate in culture medium lacking antibiotics (10 replicates per isolate). WbpM and MexAB-OprM mutants had high fitness relative to OprD mutants, as determined by a two-tailed Dunnett’s test treating oprD as the control group. C Colistin tolerance, as measured by the rate of cell killing at 2 mg/L colistin (mean + /− s.e.m; n > 5 isolates per group). Altered colistin tolerance was only found in MexAB-OprM mutants, as determined by a two-tailed Dunnett’s test treating the ancestral strain as a control group (P = 0.0091). Source data are provided as a Source Data file.