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. 2020 Dec 4;52(12):1976–1988. doi: 10.1038/s12276-020-00538-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The number of expressed ligand (left) or receptor (right) genes from the FANTOM5 database in each cell. b Putative intercellular interactions between two other cells are much more prominent than was putative self-sufficient signaling. Intercellular interaction types were indicated by ‘ligand-expressing cell (L)>receptor-expressing cell (R)’. c Strongly and commonly expressed interacting genes in tumors (left) or TAMs (right). The genes with average expression over quantile 0.95 and a fraction of expressing cells over 0.75 were labeled. d Top 10 abundant interaction pairs (>10,224 pairs in each interaction) related to c. e Strongly and commonly expressed interacting genes among the chemokine-related interactions (Supplementary Table 1a). Genes with average expression over quantile 0.5 and a fraction of expressing cells over 0.1 were labeled. f Top 10 abundant interaction pairs (>406 pairs in each interaction) related to e. g Expression level of the genes associated with macrophage function (Supplementary Table 1b) indicates high expression of CCL3, IL1B, and CCR1 in macrophages and IL1R2 in tumor cells (marked with a star). h Coexpression of IL1B and IL10 in TAMs. The x and y-axes show the expression levels of IL1B and IL10, respectively. Each dot represents a cell, and each cell was colored based on the sample origin. Expressed genes were evaluated based on threshold 1 in a–f.