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. 2021 Jan 20;53(1):136–149. doi: 10.1038/s12276-020-00552-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b Dot-plot graph depicting cytokine/chemokine genes that are differentially expressed between NTM patients and HCs. Human PBMCs were isolated from HC (n = 25) and NTM patients (Mabc, n = 22; Mmass, n = 11) and SARM1 (a) and TNIP3 (b) mRNAs were determined using quantitative real-time PCR analysis. Mann–Whitney U test. c, d Correlation analysis between SARM1 and CXCL2/CCL2 (c) and TNIP3 and CXCL2/CCL2 (d). e Human primary MDMs were transfected with mimic negative control (Control) or miR-144-3p mimic (10 nM) for 24 h and then infected with or without Mabc or Mmass (MOI = 2, for each; for 3 h). Quantitative real-time PCR analysis of TNIP3 and SARM1 expression. *p < 0.05, **p < 0.01, and ***p < 0.001. Spearman correlation (c, d); one-way ANOVA (e). Data are representative of three or four independent experiments performed in duplicate. HC healthy controls, Mabc M. abscessus subsp. abscessus, Mmass M. abscessus subsp. massiliense.