Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 6;53(1):81–90. doi: 10.1038/s12276-020-00547-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a Gene expression in lung adenocarcinoma (LUAD, n = 514) and noninvolved lung tissue (lung, n = 59) was obtained from the publicly available TCGA dataset. The genes were grouped according to their involvement in PE (phosphatidylethanolamine), PC (phosphatidylcholine), or PI (phosphatidylinositol) biosynthesis. Data were obtained via the XENA database (https://xenabrowser.net/). Group comparisons were performed by Mann–Whitney U tests. ***P < 0.001. n.s. Not significant. b Overall survival in patients with surgically treated lung adenocarcinoma showing high or low expression of the PE biosynthetic enzyme EPT1 or the PC biosynthetic enzyme CHKA (n = 491; data were retrieved via the UCSC Xena platform, https://xenabrowser.net/). Median values were used as the cutoffs. Differences in survival were assessed using the log-rank test. c Biosynthetic pathways for the different phospholipid classes.