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. 2021 Apr 28;11:9189. doi: 10.1038/s41598-021-88497-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Histological sections of liver stained with Hematoxylin & Eosin from C57BL/6 STZ-induced diabetic mice, + /- Saccharomyces boulardii (0.5 × 10⁸ colony-forming units, THT 500,101 strain, Probiotics and Starters Cultures, Belgium) for 8 weeks. Control (a) and Control treated with S. boulardii (b) show normal hepatocytes organization. The diabetic group (c) showed hepatocytes with signs of hydropic degeneration which consists in enlarged cells and clear cytoplasm due to the presence of small clear vacuoles with indistinct shape and limits (→), and in diabetic group treated with S. boulardii (d) it is attenuated.