Table 1.
Single-cell profiling of major human organs and tissues.
| Systems | Organs/tissues | Notes | References |
|---|---|---|---|
| Hematopoietic and immune system | Blood | Discovery of new types of blood cells | 95 |
| Hematopoietic differentiation | 96 | ||
| Immune cell atlas (review) | 97 | ||
| Nervous system | Brain | Transcriptional and epigenetic states | 98 |
| Human and mouse cortex | 51 | ||
| Alzheimer’s disease | 31,32 | ||
| Autism | 99 | ||
| Urinary system | Kidney | Single-nucleus RNA-seq pipeline | 100 |
| Lupus nephritis | 101 | ||
| Spatiotemporal immune topology | 102 | ||
| Respiratory system | Lung | Lung cell atlas (review) | 103 |
| Asthma | 104 | ||
| Pulmonary fibrosis | 105 | ||
| Trachea | Discovery of pulmonary “ionocytes” | 106 | |
| Hepatopancreatic–biliary | Liver | Liver cell atlas | 107 |
| Pancreas | Pancreas cell atlas | 108 | |
| Gastrointestinal system | Colon | Ulcerative colitis | 109 |
| Small intestine | Crohn’s disease | 110 | |
| Cardiovascular system | Heart | Stress-related lincRNA | 111 |
| Developmental biology | Fetal kidney | Progenitor cell dynamics and lineage | 112 |
| Fetal liver | Fetal liver hematopoiesis | 113 | |
| Fetal heart | Autoimmune-associated congenital heart block | 114 | |
| Maternal–fetal interface | Trophoblast–decidual interactions | 27 | |
| Pediatric | Pediatric cell atlas (review) | 115 | |
| Reproductive system | Breast | Breast epithelial cells | 116 |
| Testis | Testis cell atlas | 117 | |
| Sensory system | Eye | Retina cell atlas | 118,119 |