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. 2021 Apr 28;11:9220. doi: 10.1038/s41598-021-88677-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Increased ILC2 cells in the lung tissues of Tek-Cre/SHIP-1 mice. (A) Lung tissue samples of WT and Tek-Cre/SHIP-1 mice were analyzed by flow cytometry for ILC2 cells. CD45 + Lineage-ST2 + and IL-5/IL-13-producing ILC2 cells in the lung tissues of WT and Tek-Cre/SHIP-1 mice were analyzed at baseline or after Papain stimulation for 7 days. The percentage and total cell count for each sample are shown. Representative data from 3 independent experiments are shown. (B) Comparison of ILC2 cells in the lung of WT and Tek-Cre/SHIP-1 mice at baseline. Shown is fold change in mice (n = 3 each group, p = 0.048 using Student’s t test).