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. 2021 Apr 28;11:9161. doi: 10.1038/s41598-021-88150-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ATP-competitive MEK inhibitor BI-847325 does not engage nematode MEK-2. (A) The ATP-competitive MEK inhibitor BI-847325 significantly suppresses vulva induction in Wild Type and both mutants at the highest concentration tested (120 μM) relative to solvent controls (Student’s T-test: p < 0.001). The average number of vulva protrusions observed per worm in each condition quantified over 3 biological replicates is shown. Error bars indicate SEM. (A′) BI-847325 induces sterility (Ste) and embryonic lethality (Emb) phenotypes in C. elegans and C. briggsae resulting in the population growth defects indicated by the colour coded scale (nb, no bacteria remaining in the well).