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. 2020 Nov 26;52(11):1787–1797. doi: 10.1038/s12276-020-00522-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a. An example of expression quantitative trait loci (eQTLs) during brain aging. Genotypes of eQTL single-nucleotide polymorphisms (SNPs) are associated with the expression of target genes (eGenes) on the same chromosome (cis-eQTLs) or on different chromosomes (trans-eQTLs). Individuals with the GG allele in the SNP rs55675298 exhibit an age-dependent increase in the expression of the tumor protein-coding p53 family gene TP73, whereas individuals with the GT or TT allele do not. b. An example of a splicing quantitative trait locus (sQTL) in aged brains. Genotypes of sQTL SNPs are associated with alternative splicing of target genes. The number of G alleles in the SNP rs2439540 correlates positively with hnRNP splicing factors, including HNRNPA2B1, and correlates negatively with the intron usage level of TBC1 domain family member 7 (TBC1D7). Consistent with these observations, the mRNA level of HNRNPA2B1 correlates negatively with the intron usage level of TBC1D7.