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. 2021 Feb 5;53(2):223–234. doi: 10.1038/s12276-021-00559-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Volcano plot showing DEGs based on the response to ICIs with log2 (fold change in expression) >2 and P < 0.05. b Boxplot of gene expression values (DESEQ2) of CD274 and CXCL11 based on the ICI response. c Heatmap of representatively significant immune-related genes in the analysis of DEGs. d Correlation of the gene expression of CXCL11 and CD274. e Predictive value and optimal cutoff value of the CD274 gene for responsiveness using the ROC curve. f Predictive value and optimal cutoff value of the CXCL11 gene using the ROC curve. g Progression-free survival using the split level by the optimal cutoff point of CXCL11 for responsiveness using the ROC curve. h Overall survival using the split level by the optimal cutoff value of CXCL11 for responsiveness using the ROC curve. R, responder; NR, nonresponder; IHC, immunohistochemistry; ICI, immune checkpoint inhibitor; ROC, receiver operating characteristic; N/A, not available.