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. 2020 Jul 7;52(7):1004–1015. doi: 10.1038/s12276-020-0462-5

Fig. 1. The repressive mechanism of specific mRNA transcription by PcG proteins through the modification of chromatin structure.

Fig. 1

Schematic representation of transcriptional repression by PcG proteins according to the ‘hierarchical repressive model’ (a) and the ‘reverse-hierarchical repressive model’ (b). a Core subunits of PRC2 (EED, EZH, SUZ12, RBBP) recognize and repress a target locus by introducing H3K27me3. The CBX subunit of canonical PRC1 (PRC1.2 and PRC1.4) then recognizes the H3K27me3 tag, and canonical PRC1 further represses the target locus by introducing H2AK119. b The KDM2B subunit of noncanonical PRC1 (PRC1.1) recognizes CpG, and PRC1.1 represses the target locus by introducing H2AK119. The JARID2 subunit of PRC2.2 then recognizes the H2AK119 tag, and PRC2.2 further represses the target locus by introducing H3K27me3.