Table 1.
Each subunit of canonical and noncanonical polycomb complexes in mammals.
| PRC | Core subunits | Classification | Other subunits | Reference |
|---|---|---|---|---|
| PRC2.1 | EZH, EED, SUZ12, RBBP | N.D. | PCL, EPOP (C17orf96), LCOR (C10orf12) | 11 |
| PRC2.2 | EZH, EED, SUZ12, RBBP | N.D. | AEBP2, JARID2 | |
| PRC1.1 | PCGF1 (RNF68, NSPC1), RING1 | Noncanonical | RYBP, KDM2B (FBXL10), BCOR, SKP1 | 12 |
| PCGF1 (RNF68, NSPC1), RING1 | Noncanonical | YAF2, KDM2B (FBXL10), BCOR, SKP1 | ||
| PCGF1 (RNF68, NSPC1), RING1 | Noncanonical | CBX8, KDM2B (FBXL10), BCOR, SKP1 | ||
| PRC1.2 | PCGF2 (MEL-18), RING1 | Canonical | CBX, PHC, SCMH | |
| PRC1.3 | PCGF3 (RNF3), RING1 | Noncanonical | RYBP, AUTS2, FBRS, CKII (CSNK2A1) | |
| PCGF3 (RNF3), RING1 | Noncanonical | YAF2, AUTS2, FBRS, CKII (CSNK2A1) | ||
| PRC1.4 | PCGF4 (BMI-1), RING1 | Canonical | CBX, PHC, SCMH | |
| PRC1.5 | PCGF5 (RNF159), RING1 | Noncanonical | RYBP, AUTS2, FBRS, CKII (CSNK2A1) | |
| PCGF5 (RNF159), RING1 | Noncanonical | YAF2, AUTS2, FBRS, CKII (CSNK2A1) | ||
| PRC1.6 | PCGF6 (RNF134, MBLR), RING1 | Noncanonical | RYBP, WDR5, L3MBTL2, ESF6-TDP1, MGA-MAX, CBX3 (HP1γ) | |
| PCGF6 (RNF134, MBLR), RING1 | Noncanonical | YAF2, WDR5, L3MBTL2, ESF6-TDP1, MGA-MAX, CBX3 (HP1γ) |
N.D. not determined.