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. 2020 Jul 8;52(7):1090–1101. doi: 10.1038/s12276-020-0460-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Dark-adapted (DA) 8–9-week-old Abca4^−/− mice were treated by oral gavage with emixustat (EMX, 40 mg/kg, 24 h), IP-DHA (40 and 150 mg/kg, 6 h), or DHA ethyl ester (Et-ODHA 150 mg/kg, 6 h), pupils were dilated, and mice were exposed to light for 2 h. The mice were returned to the dark for 5 days before full-field ERG recordings. The a-wave amplitudes were recorded at 2-log cd.s/m² light intensity for each treatment and statistically compared to the amplitude of mice treated with the vehicle (soybean oil). Data are expressed as the mean ± SEM. Three asterisk, one-way ANOVA with Bonferroni’s multicomparison test: p < 0.001, DA (n = 12), 40 mg/kg EMX (n = 11), 150 mg/kg IP-DHA (n = 11), 40 mg/kg IP-DHA (n = 3), 150 mg/kg Et-ODHA (n = 6) vs. soybean oil (oil, n = 18); ns nonsignificant. b Chemical structures of IP-DHA, EMX, and Et-ODHA.