Table 1.
Comparison of pathological phenotype similarity between human psoriasis and Peli1 expressing mice.
| Human psoriasis | Phenotype in Peli1 expressing mice | |
|---|---|---|
| Epidermal changes | ||
| Thickening | Y | Y |
| Altered differentiation | Y | Y |
| Rete ridges | Y | Y |
| Papillomatosis | N | N |
| Vascular changes | ||
| Dilation of capillary loops | Y | Y |
| Inflammatory changes | ||
| Epidermal T cell infilteration | Y | Y |
| Intra-epidermal microabscesses | Y | Y |
| others | ||
| “Koebner” phenomenon | Y | nd |
| Phenotype dependent on immune activation | Y | Y |
| Features unlike human psoriasis | Retarded growth, hair abnormality | |
Y yes, N no, nd not yet determined.