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. 2021 Apr 28;12(5):419. doi: 10.1038/s41419-021-03695-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — y-axis: significance of rapid responses to genetic perturbations observed at day 7; x-axis: standardized (z-transformed) CRISPR score reflecting overall effects at day 28. Circles: genes with overall scores < −3.0 (essential genes) or >3.0 (anti-proliferative genes); circle sizes are scaled by the average CERES score reflecting general essentiality in cancer cells, where smaller circles indicate cell-specific dependencies, such as MDM2, CREBBP and CCND3. Genes involved in the five indicated KEGG pathways are filled with colours.