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. 2021 Apr 28;12(5):419. doi: 10.1038/s41419-021-03695-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Normalized gene enrichment scores based on RC-K8 screening results (CRISPR scores) at four time points (coloured dots) compared to enrichment scores based on previously reported screens from B-cell lymphoma cell lines (grey triangles) and 341 cancer cell lines from the CERES data (box plot). Pathways are sorted by median enrichment scores of all cell lines. T-statistics were calculated by comparing the enrichment scores between lymphoma cell lines and CERES cell lines, indicating the specificity of enrichments towards B-cell lymphoma.