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. 2020 Dec 7;52(12):1908–1925. doi: 10.1038/s12276-020-00535-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The physiological roles of CASQ1 in skeletal muscle are summarized in circles (colored blue). Within the circles, corresponding proteins, mechanisms, or events are presented in parentheses. The light purple arrow (in the lower left) indicates the process of CASQ1 polymerization. Proteins that interact with CASQ1 are listed in boxes. Greenish arrows indicate the protein complexes of CASQ1 with CASQ1-interacting proteins along with the effects of the complexes on the functions or protein activities of skeletal muscle. (+), positive or upregulation; (−), negative or downregulation. CASQ1 calsequestrin 1, DHPR dihydropyridine receptor, RyR1 ryanodine receptor 1, STIM1 stromal interaction molecule 1, JP-45 junctional protein 45, SERCA sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase, EC coupling excitation-contraction coupling, SOCE store-operated Ca²⁺ entry, ECCE Ca²⁺ entry through the DHPR during skeletal EC coupling.