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. 2020 Dec 11;52(12):2005–2019. doi: 10.1038/s12276-020-00539-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Venn diagram showing differentially expressed genes upon Acly-, Acss2-, or Crat-knockdown in C2C12 myoblasts (relative to the level of siCtl, |FC | ≥ 1.5). Numbers represent the number of commonly upregulated or downregulated (underlined) genes following siRNA treatment. The values in brackets represent gene numbers differently regulated within paired groups. b Venn diagram showing the number of downregulated genes from Acly-, Acss2-, and Crat-knockdown C2C12 myoblasts (relative to the level of the siCtl, |FC | ≥ 1.5). c GO analysis of 204 commonly downregulated genes (|FC | ≥ 1.5). The top 5 biological functions are shown in order of ascending p-values. d Heat map of differentially expressed genes associated with DNA transcription (categorized into initiation, elongation, and termination). e GO analysis of significantly upregulated genes (|FC | ≥ 1.5). The top five biological functions are shown in order of ascending p-value. Each siRNA-mediated knockdown sample was compared with the siCtl.