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. 2020 Sep 11;52(9):1486–1495. doi: 10.1038/s12276-020-00503-9

Table 1.

Peroxisomal proteins involved in peroxisome quality control.

Gene Function Reference
Peroxisome biogenesis
De novo biogenesis
 PEX3 Peroxisomal Biogenesis Factor 3 Formation of preperoxisomal vesicles 8,39,40
 PEX16 Peroxisomal Biogenesis Factor 16 Formation of preperoxisomal vesicles 10,39,40
 PEX19 Peroxisomal Biogenesis Factor 19 Receptor for mPTS membrane protein 39,40
Maturation
 PEX5 Peroxisomal Biogenesis Factor 5 Receptor for PTS1 matrix protein 45,47,48
 PEX7 Peroxisomal Biogenesis Factor 7 Receptor for PTS2 matrix protein 46
 PEX1 Peroxisomal Biogenesis Factor 1 AAA–ATPase complex for PEX5 recycling 48
 PEX6 Peroxisomal Biogenesis Factor 6 48
 PEX26 Peroxisomal Biogenesis Factor 26 48
 PEX2 Peroxisomal Biogenesis Factor 2 RING complex for PEX5 ubiquitination 48,65
 PEX10 Peroxisomal Biogenesis Factor 10 48,65
 PEX12 Peroxisomal Biogenesis Factor 12 48,65
 PEX13 Peroxisomal Biogenesis Factor 13 Docking complex for matrix protein import 8,47
 PEX14 Peroxisomal Biogenesis Factor 14 22,41
 PEX3 Peroxisomal Biogenesis Factor 3 Docking factor for PEX19 8,39,40
 PEX16 Peroxisomal Biogenesis Factor 16 Recruitment of PEX3 10,39,40
Growth and division
 PEX11β Peroxisomal Biogenesis Factor 11 Beta Interaction with DNM1L 9
 PEX11γ Peroxisomal Biogenesis Factor 11 Gamma Elongation of peroxisome and attraction of FIS1 and MFF 41
 FIS1 Fission, Mitochondrial 1 Interaction with PEX11γ and recruitment of DNM1L 41
 MFF Mitochondrial Fission Factor Interaction with PEX11γ and recruitment of DNM1L 41
 DNM1L Dynamin 1 Like Cleavage of peroxisomal membrane 9,41
Peroxisome degradation
Ub-dependent
 PEX5 Peroxisomal Biogenesis Factor 5 Target of phosphorylation and ubiquitination 59,62–64,66,69,70
 PMP70 ATP Binding Cassette Subfamily D Member 3 Target of ubiquitination 66,69
 ATM ATM Serine/Threonine Kinase Phosphorylation of PEX5 63
 PEX1 Peroxisomal Biogenesis Factor 1 Recycling of PEX5 64
 PEX26 Peroxisomal Biogenesis Factor 26 Recycling of PEX5 64
 PEX2 Peroxisomal Biogenesis Factor 2 Ubiquitination of PEX5 and PMP70 65,66,69
 USP30 Ubiquitin Specific Peptidase 30 Removal of ubiquitin from PEX5 and PMP70 68,69
 p62/SQSTM1 Sequestosome 1 Ubiquitin-binding protein 52,58,63
 NBR1 NBR1 Autophagy Cargo Receptor Ubiquitin-binding protein 57–61,66
Ub-independent
 PEX3 Peroxisomal Biogenesis Factor 3 Increase of peroxisomal ubiquitination 57
 PEX14 Peroxisomal Biogenesis Factor 14 Interaction with LC3II 57,59,70